HDAC1 and melanoma: Because, as by protein profiles (Figures 1B,C), several HDACs (HDAC-1, −2, −5, −7, and −8) appeared to be increased in FKBP51-silenced melanoma cell, we used trichostatin A (TSA) to investigate whether this agent modulated the effect of FKBP51 silencing on DR5 expression.