More specifically, LRP6 is a well-known regulator of breast cancer: LRP6 expression is frequently upregulated in breast cancer tissue, and respective overexpression or knockdown of LRP6 induces or inhibits breast tumorigenesis (Li et al., 2004; Lindvall et al., 2009; Liu et al., 2010; Zhang et al., 2010). This evidence concerns the gene LRP6 and breast cancer.