Through genome-wide screening, it was identified that a single nucleotide polymorphism (SNP) in the 1062 residue of LRP6, which converts isoleucine to valine (hereafter referred to as Ile1062Val), leads to reduced Wnt/β-catenin signaling and is implicated in Alzheimer’s disease (De Ferrari et al., 2007). Here, LRP6 is linked to early-onset autosomal dominant Alzheimer disease.