LRP6 and coronary artery disorder: Through genome-wide analysis of CAD patients, R473Q, R360H, N433S, and R611C residue mutations in LRP6 were found to be correlated with CAD pathogenesis, as determined by high glucose, lipid, and low-density lipoprotein (LDL) levels in blood vessels (Mani et al., 2007; Singh et al., 2013b).