RNF115 and cancer: Since the metabolic activity assays only give us a partial picture of the potential effects of BCA2 on tumor development and cancer progression, we next assessed whether BCA2 affects cell proliferation and migration and found that, with the exception of the non-tumor MCF-12F cells, in which endogenous BCA2 seems to reduce cell proliferation and migration, BCA2 has no major impact on these processes in the breast cancer cell lines analyzed here.