Collectively, m6A RNA methylation regulators KIAA1429, METTL16, METTL3, IGF2BP2, and YTHDF, and targets NASP, TIMP1, U2AF2, COL18A1, and VEGFA could serve as oncogenes in glioma, while PHLPP2 is a tumor suppressor. This evidence concerns the gene PHLPP2 and glioma.