In two glioma datasets, METTL3 exhibited a consistent negative relationship with TUBA4A mRNA expression (−0.35 < cor < −0.26, 9.53E-18 < p < 1.82E-09), while it had a positive association with the expressions of 15 genes, namely, DPP10, DLL3, CBX2, MEPCE, OMG, KIAA1429, SLC6A1, SOX4, SOX11, SOX2, YTHDF1, TCF3, EZH2, NASP, and NRF1 (0.21 < cor < 0.67, 1.16E-137 < p < 0.0003). The gene discussed is EZH2; the disease is central nervous system cancer.