However, this association was identified in both mRNA and protein levels of GBM (0.19 < cor < 0.47, p < 0.05), which provides support for the previous observations that METTL3 knockdown can reduce the m6A methylation, transcript, and protein levels of DLL3, HES1, and NOTCH3 in the glioblastoma stem cell line and increase cell apoptosis (Supplementary Table S4). Here, HES1 is linked to glioblastoma.