We found that METTL3 is positively associated with DLL3, HES1, and NOTCH3 expressions in glioma, especially this association that was identified in both mRNA and protein levels of GBM, which provides a support for previous observations that silencing METTL3 can reduce the transcript and protein levels of DLL3, HES1, and NOTCH3 in the glioblastoma stem cell line and increase cell apoptosis (Visvanathan et al., 2019). Here, NOTCH3 is linked to central nervous system cancer.