Additionally, we observed that METTL3 is involved in the modulation of Notch signaling pathway (including METTL3 DLL3, HES1, and NOTCH3 genes) (q-value < 0.05) (Figure 3C), which plays an important role in tumorigenesis and cancer development (Li et al., 2017). The gene discussed is DLL3; the disease is cancer.