In two glioma datasets, IGF2BP2 was negatively associated with the mRNA expression levels of 16 targets (−0.45 < cor < −0.20, 6.14E-51 < p < 0.008) and had a positive relevance with 12 targets (0.21 < cor < 0.59, 6.70E-102 < p < 0.004), among which the correlation of IGF2BP2 with SH3GL2, COL5A1, SERPINH1, and TNFRSF12A was also identified in multiple GBM and LGG datasets. Here, SERPINH1 is linked to central nervous system cancer.