As summarized in Supplementary Table S7 and Figure 3A, METTL16 showed a consistent negative correlation with NCEH1 and NOTCH3 mRNA expressions (−0.39 < cor < −0.23, 1.67E-18 < p < 7.33E-05) and had a consistent positive association with the mRNA expressions of SOX4, DLL3, RELA, and KIAA1429 in two glioma datasets (0.23 < cor < 0.46, 1.63E-171 < p < 0.0001). This evidence concerns the gene RELA and central nervous system cancer.