METTL3 and central nervous system cancer: For glioma, we found that IGF2BP2, KIAA1429, METTL16, METTL3, and YTHDF1 are consistently upregulated at the mRNA level of CGGA and GSE16011 datasets (7.97E-05 < FDR < 0.04) (Figures 1B,C and Supplementary Table S3).