Then, Lasso-penalized Cox analysis, time-dependent ROC, Kaplan–Meier curve, and multivariate Cox proportional hazard regression analysis in seven sets of mRNA datasets indicated that the seven-gene signature comprising METTL3, COL18A1, NASP, PHLPP2, TIMP1, U2AF2, and VEGFA has a good capability for predicting survival in glioma. Here, PHLPP2 is linked to central nervous system cancer.