Zhang et al. (2010) showed that a 30-days treatment with green tea polyphenols (200 mg/kg, twice a day) prominently restored blood-brain barrier permeability, rescued cerebral infarction and improved neurological functions in rats underwent cerebral ischemia. Moreover, the induction of caveolin-1 mRNA and hyperphosphorylation of extracellular signal-regulated kinase 1/2, markers of cerebral ischemia, were also found ameliorated in cerebral ischemic tissue. Liu et al. (2019) isolated four catechins, including two new catechin derivatives, from Anhua dark tea. Here, CAV1 is linked to brain ischemia.