MAPK3 and brain ischemia: Zhang et al. (2010) showed that a 30-days treatment with green tea polyphenols (200 mg/kg, twice a day) prominently restored blood-brain barrier permeability, rescued cerebral infarction and improved neurological functions in rats underwent cerebral ischemia. Moreover, the induction of caveolin-1 mRNA and hyperphosphorylation of extracellular signal-regulated kinase 1/2, markers of cerebral ischemia, were also found ameliorated in cerebral ischemic tissue. Liu et al. (2019) isolated four catechins, including two new catechin derivatives, from Anhua dark tea.