Table 2 illustrates the correlation between PDK3 immunoexpression and a variety of clinicopathological factors. In UTUC cohorts, PDK3 overexpression was associated with renal pelvis tumor (P=0.009), T2-4 stage (P <0.001), high histological grade (P=0.018), vascular invasion (P<0.001), and high mitotic rate (P<0.001). In UBUC cohorts, high PDK3 immunoexpression was associated with T2-4 stage, lymph nodes metastases, high histological grade, vascular invasion, perineural invasion, and high mitotic rate (all P<0.001). The gene discussed is PDK3; the disease is renal pelvis/ureter urothelial carcinoma.