The PB sample of Patient 5 was taken at the diagnosis of AML without known evidence of MC disease and contained the following variants: KIT p.D816V, ANO4 p.R916Q, CACNA1C p.E1913K, DNM2 p.G358R, JAK2 p.V617F, WFIKKN2 p.V82I, and NR2F6 p.P132A. The gene discussed is CACNA1C; the disease is acute myeloid leukemia.