Also, in various model pancreatic cancer cell lines, knockdown of HLA-B increased or decreased migration ability of the cells via, respectively, upregulating or downregulating the expression of integrin beta 1 (ITGB1) [a member of integrin molecules that are implicated in the upregulation of pancreatic cancer cell migration] (90). Here, ITGB1 is linked to familial pancreatic carcinoma.