Bacteroides fragilis, Bacteroides thetaiotaomicron, and Burkholderia effectively aided immunotherapy of anti-CTLA4 on MCA205 sarcomas depending on intratumoral CD11b+ DCs secreting IL-12 and splenic ICOS+ Ki67+ IFNγ+ TNFα+ T cells, and tumor-infiltrating T cells, but not Parabacteroides distasonis nor Escherichia coli nor Bacteroides uniformis (51). The gene discussed is TNF; the disease is neoplasm.