Overexpression of Drp1 induces mitochondrial fission, which can be inhibited by p53 (by activating the ROS-dependent Akt/MDM2 pathway) and increased activity of NF-κB (which induces cyclin D1 and E1 expression) to promote the proliferation of HCC cells (113). Here, AKT1 is linked to hepatocellular carcinoma.