Moreover, overexpression and knockdown of Drp1 in an orthotopic liver cancer model suggested that Drp1 increases intrahepatic lung metastasis and that Drp1-induced mitochondrial fission regulates reprogramming of the adhesion complex and lamellar pseudopodia and promotes invasion in HCC by Ca2+/calmodulin-dependent protein kinase II. This evidence concerns the gene DNM1L and hepatocellular carcinoma.