found that, after the mitochondrial fusion induced by DRP1 S637 phosphorylation, the amount and width of the mitochondrial cristae were increased, assembly of the respiratory chain complex I-IV were increased, and glycolysis mediated by the NAD/SIRT1 pathway was inhibited, ultimately promoting HCC cell survival under starvation (133). This evidence concerns the gene SIRT1 and hepatocellular carcinoma.