FOXO3 and neoplasm: Western blot analysis of the expression of FOXO3 protein and AKT/GSK3β pathway-related proteins in tumor tissues of nude mice revealed that the FOXO3 level was significantly decreased while the p-AKT (Ser473) and p-GSK3β (Ser9) levels were significantly increased in the TAM-EV-treated mice relative to those of the PBS-treated mice; the FOXO3 level was significantly increased while the p-AKT (Ser473) and p-GSK3β (Ser9) levels were significantly decreased in the TAM-In-miR-29a-3p-EV-treated mice compared with TAM-EV-treated mice (Figure 7E).