ERBB2 and neoplasm: Zhu et al. (2017) screened DNA aptamers with affinity for the HER2 protein by successively using HER2 ECD and live HER2-overexpressing SKOV3 cells. Subsequently, these aptamers were radiolabeled with isotope F18 to verify the binding of aptamers and HER2-overexpressing SKOV3 tumor model with positron emission tomography (PET), using HER2-negative MD-MBA-231 cells as the control.