KLF4 and infection: Myeloid KLF4 KO mice reached the humane endpoint of infection (level of pain, determined by department-authorized veterinarian) earlier (within 2.5 to 3.5 days post infection) compared to KLF4 WT mice (within 3 to 5 days post infection) and had to be euthanized more frequently and at earlier time points than KLF4 WT mice (Figure 1A).