POMC and Anxiety: To further explore the functions of these different bacterial genera, we evaluated correlations among the relative abundance of bacteria, hormones (including PTC, ACTH, FT3, FT4, TT3, TT4, and TSH), and the total and factor scores of HAMD (Hopelessness, Sleep disturbance, Block, Diurnal/variation, Cognitive impairment, Weight, and Anxiety/somatic) in the MDD group and those of HAMA (Psychic anxiety and Somatic anxiety) in the GAD group.