For example, it was found that GDF11 in the blood promotes nerve regeneration using the technique of heterochronic parabiosis (Katsimpardi et al., 2014), improves skeletal muscle function, and reverses ventricular hypertrophy in the aged mice (Sinha et al., 2014), highlighting GDF11 as a promising rejuvenating factor. This evidence concerns the gene GDF11 and cardiac hypertrophy.