Moreover, liver carcinogenesis has been associated with a switch between MAT1A and MAT2A (mostly expressed in foetal liver and extrahepatic tissues), resulting in a less efficient methionine metabolism that enhances HCC cell proliferation and genomic instability, as it is the case with global DNA hypomethylation (Frau et al., 2013). The gene discussed is MAT1A; the disease is hepatocellular carcinoma.