Several reports have highlighted the critical role of cysteine uptake, specifically in its oxidised form (cystine) via the cystine/glutamate exchanger SLC7A11, which supports tumour initiation and progression in PDAC (Daher et al., 2019; Badgley et al., 2020; Mukhopadhyay et al., 2021). This evidence concerns the gene SLC7A11 and neoplasm.