Arginine deprivation in GBM cells decreased cell viability, cell motility, invasiveness and adhesion; arginine deprivation resulted in decreased β-actin filament content, and in reduced β-actin arginylation (Pavlyk et al., 2015), shown to be crucial for cell migration and cardiomyocyte contractility (Kurosaka et al., 2012). Here, ACTB is linked to glioblastoma.