ACTA1 and renal fibrosis: Fibroblast-to-myofibroblast transition, a representative process among several routes of exaggerated ECM accumulation in renal fibrosis, is characterized by the expression of mesenchymal cell products such as α-SMA, vimentin (intermediate filament), and collagen I (Klingberg et al., 2013; Desai et al., 2014).