PTGS2 and Alzheimer disease: AD increased hallmarks of allergic inflammation, such as Macrophage inflammatory protein-2 (MIP-2), Thymic stromal lymphopoietin (TSLP), HDAC3, and COX2, and autophagic flux such as pAMPKαT172 and pBeclin1S14, in an HDAC6-dependent manner (Figure 1C, left).