Immunoblot of skin tissue (Figure 6C, left) and skin mast cells isolated from skin tissue of Nc/Nga mouse of each experimental group (Figure 6C, right) showed that sirtinol inhibited the effect of AD on the increased expression levels of SIRT1, HDAC6, TSLP, pBeclin1S14, and COX2. The gene discussed is PTGS2; the disease is Alzheimer disease.