SIRT1 and Alzheimer disease: Immunoblot of skin tissue (Figure 6C, left) and skin mast cells isolated from skin tissue of Nc/Nga mouse of each experimental group (Figure 6C, right) showed that sirtinol inhibited the effect of AD on the increased expression levels of SIRT1, HDAC6, TSLP, pBeclin1S14, and COX2.