Oxazolone-induced AD in SKH-1 mice (Supplementary Figure S2A, B) was accompanied by epidermal hyperplasia (Supplementary Figure S2C), an increased number of degranulated mast cells (Supplementary Figure S2C), and the increased expression levels of SIRT1, HDAC6, TSLP, and CXCL13 (Supplementary Figure S2D). The gene discussed is SIRT1; the disease is Alzheimer disease.