PGC1a can be reduced under metabolism disorder and result in disturbed mitochondria biogenesis (Santos et al., 2011; Chen et al., 2017), and it was reported that preserving PGC1a activity could effectively protect against HFD-induced diabetic cardiomyopathy (Waldman et al., 2018). The gene discussed is PPARGC1A; the disease is Other metabolic disease.