Prions protein-infecting factors, virulent prions or infectious proteins, and the cellular prion protein (PrPc), a cell surface protein encoded by the PRNP gene, is most abundantly expressed in the nervous system, and its misfolded isomer PrP (PrPSc) is key to the development of prion diseases (Ryskalin et al., 2019; Lopez-Perez et al., 2020). The gene discussed is PRNP; the disease is prion disease.