TDP-43, a major component of ubiquitinated and hyper phosphorylated cytoplasmic aggregates observed in postmortem tissues of patients with ALS, is commonly found in the brains and is a major protein in the pathogenesis of ALS (De Boer et al., 2020; Suk and Rousseaux, 2020). Here, TARDBP is linked to amyotrophic lateral sclerosis.