miR-182-5p is significantly upregulated in exosomes produced by GBM cells in a hypoxic environment, and this microRNA (miRNA) can inhibit the expression of Kruppel-like factors 2 and 4 (KLF2 and KLF4), leading to the accumulation of vascular endothelial growth factor (VEGF) receptor and promotion of tumor angiogenesis. This evidence concerns the gene KLF2 and glioblastoma.