It is recently reported that the treatment of triple negative breast cancer cells with leptin has upregulated the expression of oncogenic and chemotherapy-resistant genes including ITGB3 (integrin β3), LL22NC03, ABCB1 (p-glycoprotein 1), WNT4 (WNT4 protein), TBC1D3 (TBC1 domain family member 3E/3F), ADHFE1 (alcohol dehydrogenase, iron containing 1) and RDH5 (11-cis retinol dehydrogenase) [115]. This evidence concerns the gene RDH5 and triple-negative breast carcinoma.