As we have mentioned the opposite role of chemerin in human lymphocytes and gastric carcinoma cells with its cancer suppressive effect in the former and cancer supportive potential in the later [209], the chemerin-induced upregulation of cFOS and vinculin could possibly be attributed to the mentioned dual behavior of chemerin in hepatocellular [220,226] and gastric carcinoma [225] respectively. The gene discussed is RARRES2; the disease is cancer.