These target proteins were validated to be closely related to hyperlipemia, cardiac disease, cancer, etc., which is consistent with pharmacological activities of PB according to the top enriched GO terms and KEGG pathways (Fig. 4b, c), such as pathways in cancer (hsa05200), aldosterone-regulated sodium reabsorption (hsa04960), insulin secretion (hsa04911), regulation of cell proliferation (GO:0042127), negative regulation of insulin receptor signaling pathway (GO:0046627), and sensory perception of pain (GO:0019233). The gene discussed is INSR; the disease is familial hyperlipidemia.