GCDH and hereditary elliptocytosis: As an additional possible mechanism explaining differences between individuals with HE and LE subtype, selective glutarylation of more than 30 mitochondrial proteins exclusively localized in astroglial cells of Gcdh-deficient mice was recently demonstrated resulting in reduced catalytic activity, stability and protein–protein interaction of glutamate dehydrogenase and brain-specific carbonic anhydrase 5b.