Using rodent models of liver fibrosis, a previous study uncovered a critical role of Prrx1 in PDGF-dependent HSC migration, and an adenoviral-mediated Prrx1 short hairpin RNA (shRNA) administration reduced thioacetamide (TAA)-and CCl4-induced liver fibrosis64. This evidence concerns the gene PRRX1 and Hepatic fibrosis.