CREB3L1, also known as OASIS, was identified as another potential master regulator of HSC activation (Fig. 3a,b), as its predicted target genes include known liver fibrosis-associated genes such as COL1A1 and LOX. This observation is in agreement with a previous finding that CREB3L1-deficient mice exhibited severe osteopenia caused by a decrease in the expression of COL1A1 in the bone matrix53. This evidence concerns the gene LOX and Hepatic fibrosis.