Consistently, the expression of two well-known liver fibrosis-associated genes (e.g., Col1a1 and Lox) among the 61 shared liver fibrosis-related genes and four TF genes of interest (e.g., Runx1, Creb3l1, Aebp1 and Prrx1) showed an upward trend as disease worsens across all three rodent models (Fig. 5h–m), further confirming their translatability across human, mouse and rat for future drug discovery endeavors. This evidence concerns the gene PRRX1 and Hepatic fibrosis.