Given the preserved browning potential of the iWAT in response to cold (Supplemental Fig. 4) and the temperature-dependence of the obesity-promoting phenotype of the fKO mouse (Fig. 4i,j), it appears that altered brown fat metabolism is the main contributor to the obesigenic effect of adipose CREB3L3 ablation. The gene discussed is CREB3L3; the disease is obesity disorder.