The expression level of GLUT1 (Fig. 2b), HIF1A (Fig. 2c), phosphofructokinase (PFKL), and phosphoglycerate kinase (PGK1) were upregulated in RA-FLS (Fig. 2d) without any difference on protein content (Fig. 2e). This evidence concerns the gene PFKL and rheumatoid arthritis.