Importantly, multiple miRs (e.g. let-7g-3p, miR-3200-3p, miR-486-3p) upregulated in human SAN during HF are predicted to decrease SCN8A (Nav1.6) expression (Fig. 8), which was further confirmed by our Luciferase reporter assay experiments (Fig. S4). The gene discussed is SCN8A; the disease is hydrops fetalis.