Meanwhile, let-7a-5p, miR-1247-3p, miR-423-5p, mir-574-5p, and mir-25-5p, which are predicted to target KCNJ3/KCNJ5 genes (coding GIRK1/GIRK4), and KCNQ1/KCNE1 genes (coding IKs), were significantly downregulated in HF. The gene discussed is KCNJ3; the disease is hydrops fetalis.