In contrast, when comparing patients with and without T2D, both serum cFAS content (1.51 ± 0.75 vs. 0.95 ± 0.29; P = 0.047) and plaque FAS (14.0 ± 4.46 vs. 8.11 ± 4.93; P = 0.013) were significantly higher in patients with T2D (Fig. 3b,c). Here, FAS is linked to type 2 diabetes mellitus.