Finally, in a manner dissimilar to the other genes examined in this study, targeted demethylation of the large, highly-methylated FMR1 repeat region in Fragile X syndrome patient fibroblasts did induce basal transcription of the FMR1 gene up to a 110-fold in one cell pool suggesting that, in this case, methylation of the repeat element plays a large role in silencing of the gene. The gene discussed is FMR1; the disease is fragile X syndrome.