In addition, tail-vein assays showed that the overexpression of hsa_circ_0043280 led to a marked reduction in lung colonization by tumor cells, whereas the silencing of PAQR3 led to an increase in the metastatic colonization of the lungs by CCa cells which had been repressed by the overexpression of hsa_circ_0043280 (Fig. 5I, J). This evidence concerns the gene PAQR3 and neoplasm.