We also showed higher expression of both c-Myb mRNA and protein in BL cells, and knockdown of c-Myb in Raji and Ramos cells might induce the cleavage activation of apoptotic molecules (caspase-9, PARP) and inhibit Bcl-6 protein levels, illustrating that c-Myb plays an important role in apoptosis resistance in BL cells. This evidence concerns the gene CASP9 and Burkitt lymphoma.