When the chief axis of JAK2/STAT3 signaling is suppressed, c-MYB, as a downstream core signal, regulates the differentiation, growth and apoptosis of BL cells by crosstalk with the Bcl-6/PRDM1, c-Myc/cyclin B1 and apoptotic signaling pathways (Fig. 7). This evidence concerns the gene STAT3 and Burkitt lymphoma.