What’s more, phosphor-ERK, MMP2/9, N-cadherin, Vimentin, Snail, Slug and Twist1 were downregulated and E-cadherin was upregulated in gastric cancer cells upon exposure to PD98059 at 0, 5, 10, 20 μM for 24 h (Fig. 5B, C). This evidence concerns the gene MMP2 and gastric cancer.