Similarly, Pellino1 suppresses autoimmunity in a B cell–dependent manner as Pellino1-deficient B cells secrete autoantibodies and induce lupus-like autoimmunity in mice as Pellino1 is involved in ubiquitination and degradation of NF-κB–inducing kinase (28). The gene discussed is NFKB1; the disease is Autoimmunity.