PROK2 and hypogonadotropic hypogonadism: One individual has a de novo deletion that includes approximately 30 genes, including the entirety of FOXP1. The deletion includes two other genes associated with autosomal dominant disorders: PROK2 associated with hypogonadotropic hypogonadism 4 with or without anosmia (MIM 610628) and ROBO2, associated with vesicoureteral reflux 2 (MIM 610878).