In this study, the analysis results indicated that the lipid levels depended significantly on AF and APOE allele groups for TG, TC, LDL-C and Apo-B (all P < 0.001), and statistically significant interactions between AF and APOE allele were observed in the above 4 variables, which indicates the potential correlations in the lipid profile, APOE genotypes and pathogenesis of AF, although the APOE gene SNPs (rs429358 and rs7412) were not significant independent risk factors for AF incidence. This evidence concerns the gene APOE and atrial fibrillation.