APOC3 and hyperlipidemia: In turn, hyperlipidemia may contribute to IMN pathogenesis through key genes, including apolipoprotein A1, apolipoprotein B, apolipoprotein C3, cholesteryl ester transfer protein, and phospholipase A2 group XIIB, as reported in a genomics study using renal cortex tissue from patients with IMN and healthy controls [31].