Notably, the majority chemokine ligand, which induced cells of the immune system to enter the site of infection, CCL-2, CD80 and CD68 of TAMs, IRF5 and NOS2 of M1, CD163 and MS4A4A of M2 were strongly related to JAK1 expression in LUAD (all P value < 0.0001). The gene discussed is CCL2; the disease is infection.