As reported by Zeng et al. YEATS2 protein was co-expressed and modulated by HIF1α via hypoxia response element, besides, the inhibitory function of HIF1α knockdown on proliferation and migration could be counteracted by YEATS2 overexpression in pancreatic cancer cells (Zeng et al, 2021). Here, YEATS2 is linked to familial pancreatic carcinoma.