Some studies have additionally found indications of neuroinflammation in the cerebrospinal fluid (CSF) of patients with psychotic disorders; a recent meta-analysis [18] showed increased levels of the pro-inflammatory cytokines interleukin 6 (IL-6) and IL-8 in the CSF, as well as increased CSF/serum albumin ratio, indicating increased blood-brain barrier permeability. Here, IL6 is linked to psychotic disorder.