Moreover, DYRK1A was found to phosphorylate MUNC18-1 [93], which interacts with the SNARE complex protein Syntaxin 1A, whose transcripts are also decreased in the hippocampus of Dyrk1aC/C mice and which was found to be one of the six hubs connecting the major subnetwork biological cascades found deregulated in DS models [50]. The gene discussed is STXBP1; the disease is Dravet syndrome.