NF2 and neoplasm: Critically, in the Merlin knockdown setting, TKCC05 tumors failed to grow beyond the initial palpable stage upon combination treatment, resulting in stabilized disease [Fig. 8H, arrow, compare tumor volume between days 8 and 26 for dashed green line; Fig. 8K, pLKO.1 doubled in size (growth rate, 2.33), whereas Merlin-48 displayed stable disease (growth rate, 1.04)].