In line with the recognized role of outside-in signaling and ECM-tumor feedback in tumor progression (14, 44, 57), we next dissected the effects of epithelial and stromal FAK targeting on cell cycle progression using (i) the FUCCI biosensor, (ii) pillar plates (58, 59), and (iii) stiffness-tunable matrices (60). This evidence concerns the gene PTK2 and neoplasm.