During the process, CRC is thought to be initiated when stem cells at the bottom of the villi crypts of intestinal epithelial cells undergo mutations that make them immortal and able to accumulate additional mutations, such as adenomatous polyposis coli (APC), the β-catenin gene (CTNNB1), TP53, Kirsten rat sarcoma (KRAS), and myelocytomatosis oncogene (MYC)10. The gene discussed is APC; the disease is colorectal carcinoma.