In another example, zerumbone, the main component of Zingiber zerumbet, has been reported to have antibacterial, antiinflammatory and antitumor activities, and has been shown to reduce ETBF-induced, intestinal inflammation-related CRC by altering the IL-17, β-catenin, Stat3, and NF-κB pathways121. Here, NFKB1 is linked to colorectal carcinoma.