RASA2 and colitis: NF-κB up-regulates the expression of miR-21, a key promoter of colitis-associated colon cancer87, which in turn reduces RAS GTPase RASA1, a member of the RAS-GTPase-activating protein (RAS-GAP) family that binds to and inactivates the oncoprotein, RAS, and inhibits CRC88.