To confirm whether GPX4 and GSTM1 contribute to the notable GSH high‐consumption state in lung cancer BM, shRNAs targeting GPX4 or GSTM1 were transfected into PC9‐BrM3 cells while GPX4 or GSTM1 plasmids were transfected into parental PC9 cells, respectively. The gene discussed is GSTM1; the disease is lung carcinoma.