For example, seven of these pathway proteins identified by GO and GSEA analyses, including SRSF10, SF3A2, CSTF2, RIF1, LSM6, MRPL21, and UBE2A, are extremely highly expressed in ESCC and have well‐established tumor‐promoting roles, thus supporting them as latent targets for curative treatment of ESCC. This evidence concerns the gene RIF1 and neoplasm.