Among those DEPs between ESCC and NAT samples involved in pathways listed in Figure 3A, five of them with extremely high expression in ESCC are highlighted in Figure S9, including SRSF10, U6 snRNA‐associated Sm‐like protein LSM6, SF3A2, mitochondrial ribosomal protein L21 (MRPL21), and ubiquitin conjugating enzyme E2 A (UBE2A). The gene discussed is BRD2; the disease is esophageal squamous cell carcinoma.