Of importance, among these 480 genes, those producing proteins with extremely high levels in ESCC tissues, included serine and arginine rich splicing factor 10 (SRSF10), splicing factor 3A subunit 2 (SF3A2), cleavage stimulation factor subunit 2 (CSTF2), and replication timing regulatory factor 1 (RIF1) (Figure 2E). The gene discussed is RIF1; the disease is esophageal squamous cell carcinoma.