SPOP and neoplasm: First, we examined c‐Myb/miR‐145‐5p/SPOP/PD‐L1 pathway proteins in tumor tissues of the model mice, which showed that c‐Myb, miR‐145‐5p, and PD‐L1 expression in the tumor tissues of model mice treated with sh‐c‐Myb was decreased, while SPOP expression was increased (Figure 9A & B).