Another study revealed the relationship between IGF2BP2 and GSCs in mesenchymal GBM, where IGF2BP2, DExH‐Box helicase 9 (DHX9), and HIF1A antisense RNA 2 (HIF1A‐AS2) can directly interact to stimulate the expression of target genes (high mobility group A1 [HMGA1]), eventually driving the GBM phenotype and enabling GSCs to acclimatize to hypoxic conditions.74 This evidence concerns the gene IGF2BP2 and glioblastoma.