YTHDF1 and neoplasm: Researchers have also found that a high expression level of YTHDF1 promotes the tumorigenicity of CRC cells both in vivo and in vitro, while silencing YTHDF1 gives rise to a corresponding downregulation of classical CSC markers (CD44, CD133, OCT4, aldehyde dehydrogenase 1 [ALDH1], and leucine‐rich repeat‐containing G‐protein coupled receptor 5 [LGR5]), a smaller clonosphere, and slower tumor formation.