The data shown in our study indicate that overexpressed JMJD1C increases the expression of M1 markers (IL‐1β, TNF, CXCL9, IL‐23, ROS1, IL‐12a, and IL‐12b) both in the glioma mouse models and in the CD14+ monocytes co‐cultured with glioma cells. Here, JMJD1C is linked to central nervous system cancer.