Co‐culture of human CD14+ monocytes and glioma cells (LN‐229 or U251 cells) revealed that overexpression of METTL3 induced a decline in the number of CD86+ M1 macrophages that had differentiated from monocytes, while simultaneous overexpression of METTL3 and SOCS2 increased the number of differentiated CD86+ M1 macrophages (Figure 6H,I). The gene discussed is METTL3; the disease is central nervous system cancer.