Finally, to verify whether JMJD1C promotes the polarization of M1 macrophage to inhibit glioma development through the miR‐302a/METTL3/METTL3/SOCS2 axis, we obtained LN‐229 cells stably overexpressing JMJD1C alone or in conjunction with silencing of SOCS2, which were then inoculated to the nude mice. Here, SOCS2 is linked to central nervous system cancer.