Ultimately, although TRIB2 overexpression in ESCC cells reduced METTL14 abundance, the TRIB2 VPM mutant did not elicit an overt effect, whereas COP1 knockdown fully blocked the TRIB2 overexpression‐induced effect (Figures 5P and S6L). Here, METTL14 is linked to esophageal squamous cell carcinoma.