Intriguingly, although treatment with HDAC inhibitors had no overt effect on miR‐99a‐5p expression (Figure S3E), we observed that HDAC2 inhibitors (SCA, 2 μM) largely blocked TRIB2‐mediated growth of ESCC cells (Figures 6A and S7A). This evidence concerns the gene TRIB2 and esophageal squamous cell carcinoma.