Moreover, we identified a METTL14‐miR‐99a‐5p‐TRIB2 feedback loop in ESCC in which TRIB2 is negatively modulated by METTL14 through miR‐99a‐5p, whereas TRIB2 depletes METTL14 by potentiating METTL14 proteasomal degradation. The gene discussed is TRIB2; the disease is esophageal squamous cell carcinoma.