Single LVL administration in combination with SOC resulted in an increased sustained clinical improvement rate without requirement of rescue therapy in overweighted (BMI > 28) males and females, aged > 40 years old, with vascular and metabolism/nutrition disorders as main comorbidities, who have radiologically confirmed SARS-CoV-2 pneumonia with no signs of other active infection, requiring or not oxygen therapy (but not ventilation) with median saturation 91% [90.0–92.0] and increased CRP, ESR and IL-6 blood concentrations. The gene discussed is CRP; the disease is infection.