These findings are of particular interest because both UbcH10 and Ube2S are up-regulated in cancer cells (Pallante et al. 2005; Berlingieri et al. 2007; Ieta et al. 2007; Fujita et al. 2009; Chen et al. 2010; Shen et al. 2013; Ayesha et al. 2016; Yoshimura et al. 2017; Li et al. 2018; Pan et al. 2018; Lin et al. 2019) and their overexpression may disrupt checkpoint control and contribute to cellular transformation. This evidence concerns the gene UBE2S and cancer.