Both UbcH10 and Ube2S are overexpressed in human cancers (Pallante et al. 2005; Berlingieri et al. 2007; Ieta et al. 2007; Fujita et al. 2009; Chen et al. 2010; Shen et al. 2013; Ayesha et al. 2016; Yoshimura et al. 2017; Li et al. 2018; Pan et al. 2018; Lin et al. 2019) and elevated expression of Ube2K is associated with a poor prognosis in pancreatic and gastric cancers (Uhlen et al. 2017; Wu et al. 2020). The gene discussed is UBE2S; the disease is cancer.